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硝化棉微球的连续化工艺技术探索研究

时间:2019-10-05 20:48来源:毕业论文
微气孔球形药内部有大量微孔结构,表观燃速大幅得到提升,使得球形药在燃速性发射药和高燃速推进剂方面应用成为可能。连续化制备球形药技术已经很成熟,具有设备简单、生产周

摘要微气孔球形药内部有大量微孔结构,表观燃速大幅得到提升,使得球形药在燃速性发射药和高燃速推进剂方面应用成为可能。连续化制备球形药技术已经很成熟,具有设备简单、生产周期短、安全性好、生产成本低等优势。因此,本文探索微气孔球形药(硝化棉微球)的连续化工艺技术,并探究影响成球粒径的因素及其规律:18924
(1)溶剂比对粒径的影响:在30~100倍溶剂比条件下,平均粒径随着溶剂比的增大而减小,粒径分布也变窄。
(2)水药比对粒径的影响:在10~30倍水药比条件下,平均粒径随着水药比的增大而缓慢减小,影响不明显。
(3)乳化剂量对粒径的影响:在0.05%~0.1%乳化剂浓度条件下,平均粒径随着乳化剂量的增大而明显减小,影响显著。
(4)分散剂量对粒径的影响:在0.05%~0.1%分散剂浓度条件下,平均粒径随着分散剂量的增大而减小,符合理论预期。
(5)驱溶时间对粒径的影响:在10分钟到90分钟范围内,平均粒径随着驱溶时间延长而减小,40分钟后减小非常缓慢,可忽略不计。
(6)取样干湿程度对粒径的影响:已干球粒粒径明显大于湿球粒,与预期相反,驱溶时间不足,溶剂未去除完全。为的得到更好质量球粒,应增大驱溶时间。
关键词:硝化棉微球、连续化、粒径、溶剂比、水药比、乳化剂、分散剂
毕业设计说明书(毕业论文英文摘要
Title Exploration and research in nitrocellulose microspheres continuous  technology
Abstract
Micro-spherical pores drugs has a lot of internal pore structure, the apparent burning rate is enhanced significantly, which making the drug in the sphere of propellant burning rate and application of high burning rate propellant possible. Preparation of continuous spherical medicine technology has matured, it has many advantages, such as the simple device, short production cycle, good safety, and the tow cost. 源`自<六:维;论-文>网/www.lwfree.cn
Therefore, this article explores the micro-spherical pores drugs (nitrocellulose microspheres) continuous technology , and explore the factors that affect the particle size and its laws:
(1)Effects of solvent ratio on particle size's: at 30 to 100 times the ratio of solvent conditions, the average particle diameter ratio increases with decreasing solvent,and particle size distribution is narrower.
(2)Effects of water and propellant ratio on particle size's: at 10 to 30 times of water and propellant ratio conditions, the average particle size of the drug ratio increases as the water slowly decreases, and the impact is not obvious.
(3)Effects of emulsifier concentration on particle size's: at the 0.05% to 0.1% emulsifier concentration conditions, with the increase of the average particle size and significantly reduced the amount of emulsifier, and the impact is very significant.
(4)Effects of dispersant concentration on particle size's: at 0.05% to 0.1% dispersant concentration conditions, the average particle size increases with decreasing the amount of dispersant,in line with theoretical expectations.
(5)Effects of getting rid of solvent time on particle size's: in the range of 10 minutes to 90 minutes, with an average particle size decreases prolonged flooding dissolved, after 40 minutes reduced very slowly, it may be negligible.
(6)Effects of sampling degree of wet and dry on particle size's: wet particle size  significantly greater than dry particle size, it is contrary to expectation. We should Increases the getting rid of solvent time to get better quality nitrocellulose microspheres.
Keywords  Nitrocellulose microspheres; Continuous; Particle size; Solvent ratio; Water and propellant ratio;Emulsifier;Dispersant
目录
毕业设计说明书(论文)中文摘要    1 硝化棉微球的连续化工艺技术探索研究:http://www.lwfree.cn/huaxue/20191005/40238.html
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