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N-烷基苯氧乙酰胺的合成及表征

时间:2019-10-20 15:51来源:毕业论文
以4-苯氧基苯酚、氯乙酸甲酯为原料,以无水碳酸钾作碱性催化剂,N,N-二甲基甲酰胺(DMF)为溶剂,制备了中间体2-(4-苯氧基苯氧基)乙酸甲酯(Ⅰ);将中间体(Ⅰ)分别与甲胺和二甲胺反

摘要:以4-苯氧基苯酚、氯乙酸甲酯为原料,以无水碳酸钾作碱性催化剂,N,N-二甲基甲酰胺(DMF)为溶剂,制备了中间体2-(4-苯氧基苯氧基)乙酸甲酯(Ⅰ);将中间体(Ⅰ)分别与甲胺和二甲胺反应,得到产物N-甲基-2-(4-苯氧基苯氧基)乙酰胺(Ⅱ)和N,N-二甲基-2-(4-苯氧基苯氧基)乙酰胺(Ⅲ)。本文着重考察了反应时间、反应温度、物料投料比对中间产物(Ⅰ)和目的产物(Ⅱ)收率的影响。确定了2-(4-苯氧基苯氧基)乙酸甲酯合成工艺条件为:反应温度85℃;反应时间4.0h;物料投料比n(4-苯氧基苯酚):n(氯乙酸甲酯)=1.00:1.15。在此条件下其收率为80%左右。N-甲基-2-(4-苯氧基苯氧基)乙酰胺合成工艺条件为:反应温度25℃;反应时间3.0h;物料投料比n[2-(4-苯氧基苯氧基)乙酸甲酯]:n(甲胺)=1.0:1.3。在此条件下,其收率为89%左右。经IR和1H-NMR表征,产物为N-甲基-2-(4-苯氧基苯氧基)乙酰胺(Ⅱ)和N,N-二甲基-2-(4-苯氧基苯氧基)乙酰胺(Ⅲ)。41174
毕业论文关键词:氯乙酸甲酯;4-苯氧基苯酚;2-(4-苯氧基苯氧基)乙酸甲酯; N-甲基-2-(4-苯氧基苯氧基)乙酰胺;N,N-二甲基-2-(4-苯氧基苯氧基)乙酰胺
 TheSynthesis and Characterization of    N-alkyl-2-phenoxyacetamide
Abstract: 2-(4-phenoxyphenoxy)acetate(Ⅰ)was synthesized from methyl chloroacetate
and 4-Phenoxyphenol in fixed temperature and react several hours, add potassium-carbonate as catalyst and N,N-dimethyl formamide as organic impregnant. Then review the inf-
luence of different react time, then the intermediates (Ⅰ) reaction with methylamine and dimethylamine respectively.Lastly,we wouldget the product of N-methyl-2-(4-phenoxyphenoxy)acetamide(Ⅱ)andN,N-dimethyl-2-(4-phenoxyphenoxy)acetamide (Ⅲ).The optim-
um reaction conditions of 2-(4-phenoxyphenoxy)acetate(Ⅰ)werefollows: temperature85℃, reactiontime 4.0h,n(4-Phenmethyl2oxyphenol):n(methyl chloroacetate )=1.00:1.15. 源&自:六-维(论!文)网/www.lwfree.cn
Yieldof methyl2-(4-phenoxyphenoxy)acetatewas above 80%;and the optimum reaction-conditions of N-methyl-2-(4-phenoxyphenoxy)acetamidewere separated as follows:temper-
ature 25℃, reaction time3.0h,n[methyl 2-(4-phenoxyphenoxy)acetate] :n(methylamine)=1.0:1.3.Yieldof N-methyl-2-(4-phenoxyphenoxy)acetamidewas above 89%; By IR,1H-NMR and elemental analysis were characterized that it wereN-methyl-2-(4-phenoxypheno-
xy)acetamide(Ⅱ)andN,N-dimethyl-2-(4-phenoxyphenoxy)acetamide (Ⅲ).
Keywords:methylchloroacetate;4-phenoxyphenol;2-(4-phenoxyphenoxy)acetate;
N-methyl-2-(4-phenoxyphenoxy)acetamide;N,N-dimethyl-2-(4-phenoxyphenoxy)acetamide
目录
1 绪论    1
1.1除草剂国内外研究现状与水平    1
1.2农药发展趋势    4
1.2.1新农药创制方法    4
1.2.2世界农药市场及特点    4
1.3文献查阅、调研情况    5
1.3.1 酰胺类化合物概述    5
1.3.2 苯氧乙酰胺类的合成方法    7
1.4 本课题研究的内容及分析    9
1.4.1 本课题研究内容    9
2实验部分    12
2.1实验仪器与试剂    12
2.1.1 实验仪器    12
2.1.2 试剂及其物性常数    13
2.2产物的制备    13
2.2.1 2-(4-苯氧基苯氧基)乙酸甲酯的制备    13
2.2.2 N-甲基-2-(4-苯氧基苯氧基)乙酰胺的制备    13
2.2.3 N,N-二甲基-2-(4-苯氧基苯氧基)乙酰胺的制备    14
3结果与讨论    15 源&自:六-维(论!文)网/www.lwfree.cn
3.12-(4-苯氧基苯氧基)乙酸甲酯的制备    15
3.1.1 反应时间对2-(4-苯氧基苯氧基)乙酸甲酯收率的影响    15 N-烷基苯氧乙酰胺的合成及表征:http://www.lwfree.cn/huaxue/20191020/41151.html
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