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肉桂油层层自组装微胶囊的构建及特性初探

时间:2016-12-15 10:49来源:毕业论文
论文构建了芯材与壁材不同的浓度、pH、盐浓度对制备肉桂精油微胶囊的影响,并对其进行了粒径、zeta电位、紫外光谱图及组装层数对微胶囊体外释药时间及累积释药量的影响等测试

摘要:肉桂精油简称桂油,具有很好的抑菌作用。制备肉桂精油微胶囊在水果保鲜中的应用是替代化学药物的新方法,一方面不仅提高植物精油的使用率,另一方面也有效控制了水果的腐烂变质。本文构建了芯材与壁材不同的浓度、pH、盐浓度对制备微胶囊的影响,并对其进行了粒径、zeta电位、紫外光谱图及组装层数对微胶囊体外释药时间及累积释药量的影响等测试。当质量为0.5g时,微胶囊的沉降时间最短,成囊率最好。质量偏大或偏小对微胶囊的成囊率都有影响;pH对微胶囊凝聚相的粘度影响较大,pH低于2.0时不能形成微胶囊,pH高于5.0时微胶囊的凝聚相粘度大;盐浓度为0.1%时微胶囊的成囊表面粗糙,盐浓度高于0.6%时微胶囊粒径较大,当其浓度为0.5%时,粒径测试最小,实验效果最好;微胶囊体外释药实验中微胶囊的组装层数对微胶囊的释药性能具有一定的影响,随着组装层数的增加,在0-40h范围内,累积释放量不断增加,组装层数较少的释药速率较快。随着时间的增加,释药速率普遍缓慢。
关键词: 壳聚糖;木质素磺酸钠;肉桂油;微胶囊;层层自组装4348
Cinnamon oil layer self-assembly of microcapsules Preliminary Construction and its antibacterial properties
Abstract: Cinnamon essential oil (cinnamon oil)has great anti bacterial effects. Cinnamon essential oil microencapsulation applied in fruits preservation is a new alternative of chemical drugs. It can improving the use of plant essential oil rate,but also has effective control of fruit rot. This paper studies the effects of different salt concentration, pH, salt concentrations on the preparation of microcapsules, And has a test on the particle size, zeta potential, ultraviolet spectrogram and assembly layers of microcapsule in vitro drug release time,the influence of the cumulative release dosage test,etc. Through the experiment, the settling time of microcapsules is the shortest and the encysted rate is the best when the quality of 0.5g.Quality too large or too small have an impact on the encysted rate of the microcapsules; pH has a greater effect on the viscosity of microcapsules condensed phase, It can not be formed microcapsules when pH is less than 2.0, and the viscosity of microcapsules condensed phase would be increased when pH is above 5.0; The encysted surface of microcapsule would be roughness when salt concentration is 0.1%, the microcapusule particle size would be larger when salt concentration is above 0.6%, the test of microcapusule particle size would be smallest and the experimental effect is best when salt concentration is 0.5%; In the test of microcapsules drug release in vitro, assembly layer of microcapsules has certain effect on the drug release property of microcapsules. Microcapsules of in vitro drug release microcapsules in the experiments of assembly layer on drug release properties of microcapsules has certain influence, along with the increase of the assemble layer, within the range 0 to 40 h cumulative release a quantity to increase unceasingly, the assembly layer less faster drug release rate. With the increase of time, generally slow drug release rate. 源¥自%六:维;论-文'网=www.lwfree.cn
Key Words: chitosan; sodium lignin sulfonate; cinnamon essential oil; microcapsule; layer by layer self-assembly
目 录
1 引言    1
1.1水果的腐败变质    1
1.2肉桂精油的特点    2
1.3微胶囊试剂在水果保鲜中的应用    2
1.3.1微胶囊技术的应用    2
1.3.2 制备微胶囊的材料    3
1.4 层层自组装法概述    3
1.5 本课题的研究目的和意义    4
2 实验材料和方法    6
2.1 实验材料    6
2.1.1 肉桂精油    6
2.1.2实验试剂    6 肉桂油层层自组装微胶囊的构建及特性初探:http://www.lwfree.cn/shiping/20161215/982.html
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